Author(s): Rajesh Y. Chaudhari, Sachin S. Rane, Mahesh S. Nemade

Email(s): rychaudhari@gmail.com

DOI: 10.52711/2321-581X.2022.00014   

Address: Rajesh Y. Chaudhari*, Sachin S. Rane, Mahesh S. Nemade
Hon’ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur. Tal. Yawal, Dist. Jalgaon- 425503 Maharashtra.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2022


ABSTRACT:
A simple, robust, precise, UV spectroscopic method has been developed for the simultaneous estimation of Nebivolol and Valsartan in bulk and tablet dosage forms. In this paper the estimation of those drugs was carried out by simultaneous equation method. This method is based on measurement of absorption at 281nm and 251nm i.e, ?max of Nebivolol and Valsartan respectively. The linearity observed for Nebivolol is in the range of 5-25 µg/ml and for Valsartan is in the range of 5-80 µg/ml. The accuracy of methods was assessed by recovery studies and was found to be within the range of 99.28%-99.26% for both Nebivolol and Valsartan. The developed methods were validated with respect to linearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceutical formulations with no interference from any other excipients and diluents. The results were validated as per ICH guidelines.


Cite this article:
Rajesh Y. Chaudhari, Sachin S. Rane, Mahesh S. Nemade. Development and Validation of UV Absorbance Ratio Method for the Simultaneous Estimation of Nebivolol and Valsartan in Bulk Drugs and Pharmaceutical Dosage Form. Research Journal of Engineering and Technology. 2022; 13(4): 93-9. doi: 10.52711/2321-581X.2022.00014

Cite(Electronic):
Rajesh Y. Chaudhari, Sachin S. Rane, Mahesh S. Nemade. Development and Validation of UV Absorbance Ratio Method for the Simultaneous Estimation of Nebivolol and Valsartan in Bulk Drugs and Pharmaceutical Dosage Form. Research Journal of Engineering and Technology. 2022; 13(4): 93-9. doi: 10.52711/2321-581X.2022.00014   Available on: https://www.ijersonline.org/AbstractView.aspx?PID=2022-13-4-1


REFERENCES:
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2.    http://journals.lww.com/cardiovascularpharm/toc/1988/05000
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4.    https://en.wikipedia.org/wiki/Nebivolol
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10.    S. U. Kokil and M. S. Bhatia. Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan using RP HPLC. Indian Journal of Pharmaceutical Sciences. 2009.
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12.    Anandakumar K. And Jayamariappan M. Absorption Correction Method For The Simultaneous Estimation Of Amlodipine Besylate, Valsartan And Hydrochlorothiazide In Bulk And In Combined Tablet Dosage. International Journal of Pharmacy and Pharmaceutical Sciences. 23 Oct 2010
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